Pyroptosis is a recently discovered form of programmed cell death that is closely associated with inflammasomes，and it plays a significant role in tumor therapy.The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3) inflammasome is one of the most common inflammasomes，and it can initiate pyroptosis via the classical pathway by upregulating the expression of caspase-1 and gasdermin D(GSDMD).Natural products，known for their wide availability and structural diversity，have been extensively studied and proven to possess significant anti-tumor activities.Various natural compounds，including saponins(such as saikosaponin D and polyphyllin VI)，flavonoids(like luteolin and baicalin)，alkaloids(such as matrine and paclitaxel)，polysaccharides(like lentinan and pachymaran)，phenolic compounds(like curcumin and rhein)，terpenoids(like cucurbitacin B)，and proteins(such as trichosanthin and diosbulbin B)，have been found to modulate NLRP3 inflammasome activity and inhibit tumor progression