上皮-间质转化在胃癌的作用及中药干预机制研究进展
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国家自然科学基金项目(82305074);河南省中医药科学研究专项(2022ZY1068);河南省高等学校重点科研项目(22A360014);河南省中医药科学研究专项(2019ZYBJ12);河南省中医药拔尖人才培养项目(豫中医科教〔2018〕35号)


Role of Epithelial-mesenchymal Transition in Gastric Cancer and Research Progress on Traditional Chinese Medicine Intervention Mechanisms
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    摘要:

    胃癌作为全球范围内致死率较高的恶性肿瘤之一,是各种胃病的终末阶段,具有较高的发病率和死亡率,且严重影响患者生命质量,其防治一直备受关注。细胞上皮-间质转化(EMT)是一种细胞生物学过程,指上皮细胞转化为间质细胞的转变。细胞失去了细胞极性和细胞间连接的上皮细胞特征,同时获得了移动能力和抗凋亡能力的间质细胞的特征。近年来,EMT在肿瘤进展和转移中的重要作用逐渐成为研究热点。EMT被认为在胃癌的浸润、转移和耐药性方面起着关键作用。中医药作为一种传统的治疗方法,具有独特的优势和潜力,在治疗癌症进展中起到重要作用。越来越多的研究表明,部分中药单体及中药复方可以通过影响EMT相关因子、蛋白表达、Wnt、核因子κB、转化生长因子-β(TGF-β)等信号通路来调节EMT,从而抑制胃癌的进展。

    Abstract:

    Gastric cancer,one of the malignant tumors with high mortality rates worldwide,represents the end stage of various gastric diseases.With a high incidence and mortality rate,it severely affects the life quality of patients.Therefore,its prevention and treatment have always been of great concern.Epithelial-mesenchymal transition(EMT) is a cellular biological process that refers to the transition of epithelial cells into mesenchymal cells.During this process,cells lose the epithelial cell characteristics,such as cell polarity and intercellular connections,while acquiring the mesenchymal cell characteristics,such as mobility and apoptosis resistance.In recent years,the important role of EMT in tumor progression and metastasis has gradually become a research hotspot.EMT is believed to play a crucial role in the infiltration,metastasis,and drug resistance of gastric cancer.Traditional Chinese medicine(TCM),as a traditional treatment method with unique advantages and potential,plays an important role in cancer progression.Increasing evidence suggests that certain Chinese herbal monomers and compound formulas can regulate the EMT by affecting EMT-related factors,protein expression,signaling pathways,including Wnt,nuclear factor-κB(NF-κB),transforming growth factor-β(TGF-β),and so on,thereby inhibiting the gastric cancer progression.

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李子舜,赵长普,罗磊,陈仁伍,李美玲,王菲,郝晨源.上皮-间质转化在胃癌的作用及中药干预机制研究进展[J].世界中医药,2025,(07).

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  • 收稿日期:2024-04-07
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  • 在线发布日期: 2025-06-11
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