中医药调节复发性流产辅助性T细胞17/调节性T细胞平衡的研究进展
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金面上项目(82374505);山东省自然科学基金面上项目(ZR2023MH219);泰山学者青年专家项目(202211353)


Research Progress on the Regulation of T Helper Cell 17/Regulatory T Cell Balance in Recurrent Spontaneous Abortion by Traditional Chinese Medicine
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    复发性流产(RSA)是一种自身免疫性疾病,发病率逐年升高,其发病原因和机制复杂,辅助性T细胞17(Th17)/调节性T细胞(Treg)妊娠免疫失衡是导致RSA的重要原因。在Th17/Treg平衡中,Th17及其相关细胞因子比例增加,Th17/Treg平衡偏向Th17会诱发母体免疫耐受障碍引起免疫炎症,导致移植排斥、妊娠障碍等不良妊娠结局。RSA的发病机制尚不明确,早期诊疗困难,西医目前采用多种治疗策略进行经验性治疗,其临床疗效欠佳。RSA在中医学中属于“滑胎”范畴,强调预培其损,补肾健脾,益气养血。动物实验中,中医药通过调节Th17/Treg平衡改善孕鼠蜕膜组织形态和血流供应,增加子宫净重治疗RAS,诸多临床试验也证明了中医药以其多靶点、多途径、低毒性的优势调节Th17/Treg平衡改善RSA患者子宫内膜厚度和激素水平,来降低复发性流产率。中医药可提高RSA患者的Treg水平,降低Th17水平,调控Th17/Treg平衡,提高临床妊娠率。

    Abstract:

    Recurrent spontaneous abortion(RSA) is an autoimmune disease with an increasing incidence as well as complex pathogenesis and mechanisms.The pregnancy immune imbalance of helper T cell 17(Th17)/regulatory T cells(Treg) is an important cause of RSA.In the Th17/Treg balance,the proportion of Th17 and its related cytokines increases,and the Th17/Treg balance tends to Th17,which will induce maternal immune tolerance dysfunction and immune inflammation,leading to adverse pregnancy outcomes such as implantation rejection and pregnancy dysfunction.Due to unclear pathogenesis,the early diagnosis and treatment of RSA are difficult.Currently,Western medicine conducts empirical treatment using various strategies,but its clinical efficacy is not ideal.In traditional Chinese medicine(TCM),RSA falls in the scope of “habitual abortion”.TCM emphasizes the preventive treatment of insufficiency,nourishing the kidney and spleen,as well as invigorating qi and nourishing blood.In animal experiments,TCM has improved the decidual tissue morphology and the blood supply of pregnant mice by regulating the Th17/Treg balance,as well as increasing the uterine net weight to treat RAS.Additionally,many clinical trials have proven that TCM,with its advantages of multi-target,multi-pathway,and low toxicity,can regulate the Th17/Treg balance,and improve the uterine lining thickness and hormone levels to reduce the RSA rate.Therefore,TCM can increase the Treg cell levels,reduce the Th17 cell levels,and regulate the Th17/Treg balance in RSA patients,improving the clinical pregnancy rate.

    参考文献
    相似文献
    引证文献
引用本文

石梦雨,贾志诚,杨鑫鑫,李永谦,王培璇,郭颖.中医药调节复发性流产辅助性T细胞17/调节性T细胞平衡的研究进展[J].世界中医药,2025,(07).

复制
相关视频

分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-04-28
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2025-06-11
  • 出版日期:
文章二维码