The ischemic stroke(IS) belongs to the category of “stroke” in traditional Chinese medicine.Currently，drugs that alleviate nerve damage caused by IS have limited effects on repairing nerves.Studies have found that the process of employing acupuncture for IS treatment mainly depends on the neural stem cells in the neurogerminal center，which affects the function of the central nervous system via the neuroendocrineimmune mechanism to repair damaged neurons and neuroglial cells and accelerate the repair process.However，the number of endogenous neural stem cells(ENSC) is very limited，which can not meet the requirements for IS recovery.Electroacupuncture(EA) combined with stem cell transplantation can play a better role.On the one hand，exogenous stem cells can replace ENSC，while the addition of EA can play a synergistic effect with stem cells.On the other hand，continuous and stable stimulation of EA can improve the homing efficiency and survival rate of transplanted cells，promote the stem cells to play their role，and further improve nerve injury.Therefore，it is expected that this treatment will become a new way to treat IS.