As the most common malignant bone tumor in the clinic，osteosarcoma(OS) is frequent in adolescents.With a high malignant degree，OS extensively invades，leading to a poor prognosis while seriously threatening adolescent health.Currently，the standard therapy for OS mainly includes surgical resection and auxiliary chemotherapy.However，limb function is affected after extensive resection while chemotherapy medicines have obvious side effects，placing the OS treatment into a platform period.In contrast，traditional Chinese medicine(TCM) treatment can arrest the OS cell cycle and reduce its proliferation and colony formation capabilities.Additionally，by mediating relevant pathogenesis activity to suppress the malignant proliferation of OS，TCM can regulate OS cell apoptosis，with a wide application prospect.