基于开阖枢理论探析特发性肺纤维化的病机与辨治
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国家自然科学基金项目(82205079)——基于MUC1介导的上皮间质转化探讨养阴益气方抑制肺纤维化进展的机制研究;山西省科技厅自然科学研究面上项目(202303021211239)——补肾益肺消癥方调控FGF10/FGFrs信号通路治疗肺纤维化的作用机制研究


Pathogenesis,Syndrome Differentiation,and Treatment of Idiopathic Pulmonary Fibrosis Based on Opening,Closing,and Pivot Theory
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    摘要:

    特发性肺纤维化(IPF)是一种病因不明的慢性、进行性、致死性肺疾病,属中医学“肺痹”“肺痿”等范畴。从中医开阖枢理论出发,结合本虚、痰浊、瘀血、邪毒等病理因素,考究IPF病机主要涉及太阳开与阳明阖失常、太阴开与少阴枢失常、厥阴阖与太阴开失常。基于开阖枢理论治疗IPF,重在开太阳之气祛外扰之邪,枢少阴之气除痰瘀之痹,阖厥阴之气达肺金之降,兼以复阳明阖和太阴开机之能,通过灵活施治,使开、阖、枢气机通畅,阴阳和则化生万物,虚复、痰消、瘀除、邪去,肺清肃之性得复。

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    Idiopathic pulmonary fibrosis(IPF) is a chronic,progressive,and fatal lung disease of unknown etiology,which belongs to the “lung impediment” and “lung atrophy”.From the opening,closing,and pivot theory and combined with pathological factors of deficiency,phlegm,blood stasis,and pathogenic toxin,the pathogenesis of IPF could be summarized as a malfunction of the opening of greater yang and the closing of yang brightness,the opening of greater yin and the pivot of lesser yin,as well as the closing of reverting yin and the opening of the greater yin.Based on the opening,closing,and pivot theory,the treatment of IPF focuses on opening the qi of greater yang to banish the pathogen of external disturbance,pivoting the qi of lesser yin to eliminate phlegm and blood stasis,as well as closing the qi of reverting yin to descend the lung.In addition,it is combined with closing yang brightness and opening greater yin.By flexible treatment,the opening,closing,and pivot are smooth.Then,the harmony of yin and yang will generate everything to restore deficiency,eliminate phlegm and blood stasis,remove evil,and purify the lung.

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贺晋芳,晏军,孟丽红,张迪,薛晓明.基于开阖枢理论探析特发性肺纤维化的病机与辨治[J].世界中医药,2025,(08).

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  • 收稿日期:2024-04-19
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  • 在线发布日期: 2025-06-17
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