中医药防治呼吸道合胞病毒感染的作用机制研究进展
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国家中医药管理局2020年小儿肺炎传承创新平台建设项目(2020-1)


Research Progress on Mechanism of Traditional Chinese Medicine in Preventing and Treating Respiratory Syncytial Virus Infection
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    摘要:

    呼吸道合胞病毒(RSV)是儿童急性呼吸道感染的主要病原体,可导致肺炎、哮喘等严重并发症。目前西医缺乏特效疗法,中医药防治RSV感染临床疗效显著。现代实验研究主要从抗炎、抑制病毒复制、调节机体免疫功能、调节代谢紊乱4个方面证实了中药活性成分及中医经方有抗RSV作用。中医药可通过“病毒—宿主—免疫”多维防治RSV感染,具有直接抗病毒与恢复机体稳态优势。目前研究在阐明复方有效成分、药物协同作用靶点及增效机制等方面尚有不足。

    Abstract:

    Respiratory syncytial virus(RSV) is a leading pathogen causing acute respiratory infections in children,which can lead to severe complications such as pneumonia and asthma.Currently,Western medicine lacks specific and effective treatments for RSV infection.Traditional Chinese medicine(TCM) has demonstrated significant clinical efficacy in preventing and treating RSV infection.Modern experimental studies have confirmed that active components of Chinese herbal medicines and classical TCM formulas exert anti-RSV effects mainly through mechanisms including anti-inflammation,inhibition of viral replication,modulation of host immune responses,and regulation of metabolic disorders.TCM provides a multidimensional therapeutic approach targeting the “virus-host-immune” axis,offering both direct antiviral effects and restoration of host homeostasis.However,current research remains insufficient in elucidating the active components of compound formulas,synergistic drug targets,and mechanisms underlying enhanced therapeutic efficacy.

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刘惠煜,董立,郭腾徽,周朋.中医药防治呼吸道合胞病毒感染的作用机制研究进展[J].世界中医药,2025,(11).

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  • 收稿日期:2025-01-12
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  • 在线发布日期: 2025-08-04
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