| 引用本文:朱立群 何晓红 赵玲 陈紫苓 杨广山 卢霭华 魏华.益气补肾活血排毒中药治疗氮质血症期糖尿病肾病的疗效观察[J].世界中医药,2007,2(1):. |
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| 益气补肾活血排毒中药治疗氮质血症期糖尿病肾病的疗效观察 |
| Observations on Curative Effect of Diabetic Nephropathy at Azotemic Stage Treated by Chinese Materia Medica with Function of Supplementing Qi,Tonifying Kidney,Activating Blood Circulation and Repelling Toxin |
| 投稿时间：2006-09-01 |
| DOI： |
| 中文关键词: 糖尿病肾病，氮质血症期/中西医结合疗法 @ 益气活血补肾排毒中药 |
| English Keywords:Diabetic nephropathy,Azotemic stage / Therapy of integrated Chinese and western medicine @ Chinese materia medica with function of supplementing qi,tonifying kidney,activating blood circulation and repelling toxin |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨中西医结合治疗氮质血症期糖尿病(Diabetic Nephropathy at Azotemic Stage,DNAS)的临床疗效。方法：将血肌酐在265μmol/L水平的DNAS患者随机分为A、B两组。A组DNAS患者行常规多因素(血糖、血压、血脂等)西药强化控制治疗。B组在常规多因素西药强化控制治疗的基础上，加用益气活血补肾排毒中药进行中西医结合治疗。另设C组，为血肌酐在385~517μmol/L水平的DNAS患者，在上述中西药结合治疗的基础上，还采用中药保留灌肠治疗。以上各组DNAS患者均给予低蛋白饮食+a 酮酸(lpd+aka)疗法。结果：A组患者治疗后血肌酐(Scr)、尿素氮(BUN)、内皮素(ET 1)及24h尿蛋白排泄水平与治疗前相比有明显下降(P<005或P<001)；B组患者治疗后Scr、BUN、ET 1及24h 尿蛋白排泄水平下降更为明显，与治疗前相比有明显差异(P<001)。C组患者治疗后Scr、BUN、ET 1及24h尿蛋白排泄水平的下降与治疗前相比也有明显统计学意义(P均<001)。结论：对于DNAS患者，lpd+aka疗法和多因素西药强化控制疗法能使DNAS患者Scr、BUN、ET 1及24h 尿蛋白排泄水平明显下降，在此基础上加用益气活血补肾排毒中药治疗后，效果更明显。对于Scr在较高水平(C组)DNAS患者，采用中西医结合及中药保留灌肠进行治疗仍能够获得较满意的疗效。 |
| English Summary: |
| To explore the clinical curative effect of the therapy of integrated Chinese and western medicine on treatment of diabetic nephropathy at azotemic stage (DNAS).Methods:67 cases of DNAS with serum creatinine level at 265μmol/L were randomly divided into 2 groups (32 cases in Group A and 35 cases in Group B).Patients of group A were treated by the therapy of routine multifactorial potentialized control (MPC) of blood sugar,blood pressure and blood fat with western medicine.Patients of group B were treated by MPC therapy plus some Chinese materia medica with function of supplementing Qi,tonifying kidney,activating blood circulation and repelling toxin.Another group of patients of DNAS with serum creatinine level between 385～517 μmol/L (Group C) were treated with MPC therapy and Chinese materia medica referred above as well as the therapy of retention enema of decoction of Chinese materia medica.All the patients mentioned above were given low protein diet plus a keto acid therapy.Results:After treatment,levels of Serum creatinine (Scr),Blood Urea Nitrogen(BUN),Endothelin 1(ET 1) and quantitative examination of 24hour urinary protein of patients of group A were obviously reduced (P<0.05 or P<0.01).Levels of Scr,BUN,ET 1 and 24hour urinary protein of patients of group B and group C were significantly reduced after treatment(P<0.01).Conclusion:For patients of DNAS,the therapy of lpd with aka plus MPC with western medicine were able to effectively reduce the levels of Scr,BUN,ET 1 and 24hour urinary protein.On the basis of MPC therapy,the results of treatment were even better after adding Chinese materia medica with function of supplementing Qi,tonifying kidney,activating blood circulation and repelling toxin.For the patients of DNAS whose Scr level were comparatively higher (such as patients of group C),the treatment with integrated Chinese and western medicine as well as the therapy of retention enema of decoction of Chinese materia medica also produced satisfactory curative effect. |
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