| 引用本文:蒋可，罗侃.喘咳宁方治疗发作期哮喘的实验研究[J].世界中医药,2007,2(3):. |
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| 喘咳宁方治疗发作期哮喘的实验研究 |
| Empirical Study of Kechuanning in Treatment of Asthma at Period of Onset |
| 投稿时间：2007-03-06 |
| DOI： |
| 中文关键词: 哮喘／中医药疗法 @ 咳喘宁 |
| English Keywords:Asthma at period of onset/ Chinese medical therapy @ Kechuanning |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨中药咳喘宁方在治疗哮喘中的作用和可能的机制，为治疗哮喘提供依据。方法：将60只小鼠随机分为6组，除正常对照组外，其余各组小鼠均于实验第1、7、14日腹腔注射0.2mg/ml抗原液，并于第14日超声雾化吸入0.05%卵蛋白，连续14日。正常对照组每日予生理盐水。地塞米松对照组、低、中、高剂量咳喘宁组分别以0.0617mg/ml地塞米松、98.7mg/ml、197.4mg/ml、394.8mg/ml咳喘宁治疗。采用免疫组化染色法，比较各组BALF中TGF-β水平。结果：发作期哮喘小鼠BALF中TGF-β水平较正常对照组显著升高。结论：咳喘宁方治疗发作期哮喘的可能机制是抑制TGF-β的产生。 |
| English Summary: |
| To explore functions and possible mechanism of a Chinese medical prescription-Kechuanning and provide evidences for treatment of asthma. 〖WTHZ〗Methods: 60 mice were randomly divided into 6 groups, all of which were given 0.2mg/ml antigen solution at 1, 7, 14 day, except for the normal control group, then inhaled 0.05% egg albumin by ultrasonic atomization for 14 consecutive days. The normal control group was given sodium chloride everyday. Treatment groups were treated respectively with 0.0617mg/ml Corson, 98.7mg/ml、197.4mg/ml、394.8mg/ml Kechuanning. Immuno-histrochemical staining method was used to compare levels of TGF-β in BALF. Results: level of TGF-β in BALF rose remarkably as compared to that of the normal control group. Conclusion: The result suggested that Kechuanning's performed its functions through inhibition of production of TGF-β. |
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