To observe the impact of Qingzao Jiufeitang (Qingzao Jiufei Decoction) on content of TNF-α, MCP-1 and NO in lung cell homogenate of mice contracted with influenza virus FM1, and investigate the protective mechanism of Qingzao Jiufeitang (Qingzao Jiufei Decoction). Methods: Models of viral pneumonia in mice were replicated by inhaling FM1 via mice’s noses. The treatment group was treated with Qingzao Jiufeitang (Qingzao Jiufei Decoction), while control group with Ribavirin. We executed mice on 3rd, 6th,9th day respectively, prepared lung cell homogenate, therein detected content of TNF-α, MCP-1 and NO, and observed their dynamic changes. Results:In comparison with the model group, the content of TNF-α, MCP-1 , NO of the treatment group were significantly lower on 6th day(P<0.05, P<0.05, P<0.05)and on 9th day(P<0.01, P<0.05, P<0.01)respectively. Conclusions:Qingzao Jiufeitang (Qingzao Jiufei Decoction) can protect mice contracted with influenza virus FM1, and lessen immunizing damage in lung tissues, the mechanism of which may relate to reducing infiltration of immunocell in lung tissues, and cutting down the level of toxic inflammatory factors, like TNF-α, chemotactic factor for example, MCP-1 and inflammatory mediator, such as NO.