| 引用本文:胡心伟，指导：陆华.实验性肾虚血瘀动物模型的建立和评价[J].世界中医药,2007,2(6):. |
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| 实验性肾虚血瘀动物模型的建立和评价 |
| Establishment and Evaluation of Model of Kidney Deficiency-Blood Stagnation in Lab Animal |
| 投稿时间：2007-07-18 |
| DOI： |
| 中文关键词: 肾虚，血瘀/动物模型 |
| English Keywords:kidney deficiency, blood stagnation/ lab animal model |
| 基金项目: |
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| 摘要点击次数: 1068 |
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| 中文摘要: |
| 目的：寻找有助于评价补肾化瘀促卵泡发育及排卵药效的动物模型。方法：对单纯孕激素避孕药LNG、癸息汤所致排卵抑制模型的血液流变学、血清E2、P、卵巢、子宫指数、卵巢生长卵泡、成熟卵泡、闭锁卵泡、黄体数等指标进行考察，与正常对照组相比较。结果：孕激素LNG及癸息汤所致的动物模型出现不同程度的血黏滞度升高，生长卵泡、闭锁卵泡数增多，黄体数明显减少，孕激素水平低下。其中，血液流变学的改变以癸息汤组明显，排卵抑制以孕激素组较为明显。结论：孕激素LNG及癸息汤所致排卵抑制动物模型可初步用于补肾活血促排卵方药的药效研究及疗效判定。 |
| English Summary: |
| to search for model of laboratory animal suitable for facilitation of evaluating follicular development and ovulation by tonifying kidney and removing stasis. Method:several parameters were observed and compared between the model of ovulation inhibition induced by pure lutin contraceptive(LNG) or Guixi Decoction and the normal control group, for instance, blood rheology, blood serum E2, P, index of ovaries and hystera, growing follicle of ovaries, vesicula graafianae, corpora atretica, amount of corepus luteum, etc. Result:the model groups presented with a rise in blood viscosity, amount of growing follicle and corpora atretica to varied degrees, a marked decrease in amount of corepus luteum and depression of lutin level. Guixi Decoction group appeared significant change in blood rheology; lutin group was notable in arresting ovulation. Conclusion:animal model of arresting ovulation induced by lutin or Guixi Decoction could be used to study drug action and therapeutic effect for ovulation-facilitating medicine with the nature of tonifying kidney and removing stasis. |
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