To evaluate the clinical effect of an oral Chinese medicinal-Qianglie Shutong Jiaonang-with regular ejaculation for CPPS. Methods:312 CPPS patients were randomly divided into an experimental group (162 patients, treated with the capsules in addition to regular ejaculation) and a control group (150 patients, taking the capsules only). The main parameters were collected before and 3 months after the treatment. Results:Total effective rates of the experimental and control groups were 91.2% and 67.5% respectively. The scores on NIH CPSI for the experimental group are significantly higher than those for the control group (P<0.05). Conclusions:The combined therapy was more effective than single use of Qianlie Shutong Jiaonang for the treatment of CPPS.