世界中医药

作者	单位
赵映前¹，刘建忠¹，刘静²，肖明中¹，金伟伟¹	1 湖北省中医院，武汉市花园山4号，430061； 2 湖北中医学院2004级博士班

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中文摘要:

目的：观察扶正抗艾颗粒对无症状期和发病期属“气虚瘀毒” 证艾滋病的临床治疗作用。方法：采用自身前后对照研究，选择30例HIV/AIDS患者，疗程为5个月，观察患者治疗前后病毒载量、免疫功能、症状体征积分、趋化因子及受体等多项评价指标的变化。结果：HIV/AIDS患者治疗后主要症状、次要症状、主要体征总积分变化及卡洛夫斯基积分与治疗前相比均有统计学意义（P<0.05或P<0.01），尤其是对乏力、纳呆、脱发、腹胀、肌肉痛等症状改善明显（P<0.05）；服药后对病毒载量、CD4计数有稳定作用；治疗后趋化因子受体CCR5、CXCR4较疗前明显减少，同时趋化因子RANTES、SDF-1也减少，有统计学意义（P<0.05或P<0.01）；MIP-1α较前减少，MIP-1β较前增加，但其变化无统计学意义（P>0.05）；治疗结束后所有患者均未见明显不良反应。结论：扶正抗艾颗粒能有效改善HIV/AIDS患者临床体征，能较好保护和提高患者免疫功能，稳定病毒载量，对中医辨证属“气虚瘀毒”证的艾滋病有较好的疗效。

English Summary:

to investigate the clinical therapeutic effect of Healthy qi-Reinforcing Anti-Aids Granule for aids of type of qi deficiency and stagnating toxin at symptomless and onset periods.Methods:30 HIV/AIDS patients were examined before and after a treatment course of 5 months. Detected were such parameters as virus load,immunological function，symptoms and physical signs points，chemotatic factors and theirs receptors.Results:there were significant differences before and after treatment in scores of total symptoms (primary and secondary symptoms), scores of general physical signs (primary and secondary symptoms and main signs), and Karnofsky performance scores（P<0.05 or P<0.01）. Symptoms as fatigue, anorexia, hair loss, abdominal distension, muscle pain in particular were dramatically improved (P<0.05). The medication maintained CD4 level and virus load under a stable condition. Expressions of CCR5、CXCR4 and RANTES、SDF-1 were dramatically declined after treatment (P<0.05 or P<0.01) with a moderate increase in MIP-1α and a slight decline in MIP-1β(P>0.05); No notable adverse effects were shown in the patients.Conclusion:Healthy qi-Reinforcing Anti-Aids Granule can significantly alleviate clinical syndromes of patients with HIV/AIDS, improve immunological functions and maintain virus load, thus have good effect on aids of type of qi deficiency and stagnating toxin.

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