To evaluate the clinical efficacy of blood activation and qi replenishment method on patients with chronic epididymitis.Methods:A total of 120 Epididymitis cases were randomly divided into two groups, namely, the treatment group orally taken Danhong Semens Dredging Decoction and the control group orally taken levofloxacin. Both groups were documented in accordance with the changes of Color Doppler ultrasonogram after 60 days.Results:Both groups showed significant improvement before and after treatment (P<0.05). The treatment group was significantly better in the changes of Color Doppler ultrasonogram improvement as compared with the control group, and the differences were significant (P<0.05).Conclusion:blood activation and qi replenishment method has a definite therapeutic effect on chronic epididymitis.