To observe the effect of Rougan Fang (Liver-emolliating formula) on the function of liver and duplication of HBV (hepatitis B virus).Methods:100 patients with CHB were equally dispatched into 2 groups and were respectively administrated with Rougan Fang and Qianggan Jiaonang (Liver-tonifying Capsule)，then all the indexes and their clinic symptoms were observed.Results:By comparison to the control group，patients in the treatment group with Rougan Fang were significantly better in many aspects (P<0.05)，e.g. the elimination of the hepatitis B virus marker、symptoms and the physical signs、improvement of liver function and other indexes.Conclusion:Rougan Fang could effectively inhibit the duplication of HBV and improve the liver function.