to observe clinical effectiveness and safety of integrative Chinese and western medicine on treatment of chronic hepatitis B of negative HBeAg.Methods:144 patients were randomly selected for trials in the ratio 3:1. Among final 136 subjects，102 subjects were given Shugan Fuzheng Heji (Liver- soothing health restoring composition) plus IFN-α2b (manufacturer: Beijing Interferon Pharmaceuticals. Co.) for a treatment course of 6 months; the control group was treated with IFN-α2b only. Symptoms，physical signs，liver function，HBV-DNA，imageology index，and clinical effectiveness were observed before and after treatment.Results:after six months of treatment，the effective rate of treatment group was 62.75% and the control group，41.18% with a significant difference (P<0.05)，but total effective rates were not significantly different (P>0.05). In the six month follow-up，the treatment group had a significantly higher rate of HBV-DNA negative conversion rate in comparison with that of the control group(P<0.05); after treatment，ALT and AST levels were decreased in both groups (P<0.01)，and there was no significant difference between two groups.Conclusion:integrated Chinese and western medical treatment is effective and safe for chronic hepatitis B of negative HBeAg.