| 引用本文:谷灿立 张振强 付月箫 李新强 杨韶峰.中西医结合治疗HBeAg阴性慢性乙型肝炎的临床研究[J].世界中医药,2008,3(4):. |
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| 中西医结合治疗HBeAg阴性慢性乙型肝炎的临床研究 |
| Clinical Study of Treating Chronic Hepatitis B of Negative HBeAg with Integrative Chinese and Western Medicine |
| 投稿时间：2007-08-29 |
| DOI： |
| 中文关键词: HBeAg阴性慢性乙型肝炎/中西医结合疗法 |
| English Keywords:Chronic Hepatitis B of Negative HBeAg/ Integrative Chinese and Western Medial Treatments |
| 基金项目: |
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| 中文摘要: |
| 目的：观察中西医结合治疗HBeAg阴性慢性乙型肝炎的临床疗效及安全性。方法：将144例患者按照数字随机法以3：1的比例依次纳入观察对象，最后纳入评价者136例，其中治疗组102例给予疏肝扶正合剂，同时联用北京远策药业有限责任公司生产的远策素(干扰素IFN-α2b)5MU，6个月为1个疗程；对照组单用远策素(干扰素IFN-α2b)治疗，用法同治疗组。分别于治疗前后评价症状、体征、肝功能、HBV-DNA、影像学指标和临床综合疗效。结果：治疗组和对照组的近期(治疗6个月后)基本有效率分别为62.75%及41.18%，两组比较差异有显著性，治疗组明显高于对照组(P<0.05)，而总有效率差异无统计学意义(P>0.05)；随访6个月时，治疗组HBV-DNA阴转率明显高于对照组（P<0.05）；治疗6个月与治疗前比较，两组ALT、AST均有明显下降，差异有统计学意义（P<0.01），组间比较差异无统计学意义(P>0.05)。结论：中西医结合治疗HBeAg阴性慢性乙型肝炎疗效显著，安全性好。 |
| English Summary: |
| to observe clinical effectiveness and safety of integrative Chinese and western medicine on treatment of chronic hepatitis B of negative HBeAg.Methods:144 patients were randomly selected for trials in the ratio 3:1. Among final 136 subjects，102 subjects were given Shugan Fuzheng Heji (Liver- soothing health restoring composition) plus IFN-α2b (manufacturer: Beijing Interferon Pharmaceuticals. Co.) for a treatment course of 6 months; the control group was treated with IFN-α2b only. Symptoms，physical signs，liver function，HBV-DNA，imageology index，and clinical effectiveness were observed before and after treatment.Results:after six months of treatment，the effective rate of treatment group was 62.75% and the control group，41.18% with a significant difference (P<0.05)，but total effective rates were not significantly different (P>0.05). In the six month follow-up，the treatment group had a significantly higher rate of HBV-DNA negative conversion rate in comparison with that of the control group(P<0.05); after treatment，ALT and AST levels were decreased in both groups (P<0.01)，and there was no significant difference between two groups.Conclusion:integrated Chinese and western medical treatment is effective and safe for chronic hepatitis B of negative HBeAg. |
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