世界中医药

目的：探索肺癌中医实证证候要素与临床因素的相互关系及证的动态性演变规律，以期指导临床和提示预后。方法：采用临床流行病学调查方法收集123例肺癌患者的病历和四诊资料，并分为无实证要素和血瘀要素、气滞要素、寒凝要素、热毒要素、痰湿要素5种证候要素。并应用单因素方差分析、卡方检验与秩和检验分析证型和临床相关因素（性别、年龄、肿瘤部位、ECOG评分、临床分期和治疗方法等）的关系。结果：痰湿证候要素占了总例数的55.3％，是肺癌发生发展的证候基础。热毒要素主要出现在疾病的晚期，有一定的预后作用。结论：痰湿要素在肺癌的实证要素与临床相关因素的单因素分析中是主导的证候要素。

English Summary:

To guide the clinic practice and facilitate the prognosis，the dynamic developing relation between these essential factors in lung cancer of the excessive syndrome defined by TCM theory and those of clinical was explored.Methods:Case files and four-examination records of 123 lung cancer patients were collected with the method of clinic epidemiological investigation and were also sorted into 5 kinds of essential syndrome factors，which were factor without excessive syndrome，factor with blood stasis，factor with qi stagnation，factor with cold coagulation，factor with heat toxin and factor with phlegm-damp. With the application of one-factor analysis of variance、chi-square test and rank test，the relationship between syndrome and relevant clinic factors (for instance: gender，age，position of tumor，ECOG grades，clinic stages and treating method ) were analyzed.Results:The syndrome with phlegm-damp factor accounted for 55.3%，hence it was considered as the basic syndrome pattern of the lung cancer. The heat-toxin factor is mainly present in the later stage，which could be used to indicate the prognosis.Conclusion:Among all the factors of the lung cancer，it was the phlegm-damp that played an important role according to the one-factor analysis of variance between the excessive syndrome of lung cancer and the relevant clinic factors.

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