| 引用本文:罗明富，李翠红，张栋，郭莹，何俊娜，马惠敏，王叔友，李顺月.白脉膏剂贴敷对裸鼠穴区组织内血管和肥大细胞的影响[J].世界中医药,2008,3(6):. |
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| 白脉膏剂贴敷对裸鼠穴区组织内血管和肥大细胞的影响 |
| Effect of Baimai Paste Medicated on Acupuncture Points on Blood Vessels and Mastocytes of Nude Mice |
| 投稿时间：2008-06-19 |
| DOI： |
| 中文关键词: 穴位贴敷 @ 白脉膏剂 |
| English Keywords:Plaster Application on Acupuncture points @ Baimai Paste |
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| 中文摘要: |
| 目的: 通过体表穴区贴敷白脉膏剂，观察裸鼠皮肤组织血管和肥大细胞数量的变化，以了解该药物对组织微循环血流的作用。方法: BALB/C-nu成年裸鼠15只，分为白脉膏剂贴敷组和对照组。动物贴敷白脉膏剂7天后，分别在2组动物的背部取涂药部位（以第4胸椎为中心）和同体未涂药部位，以及对照组相应部位的皮肤组织，进行切片染色观察。结果: 在涂白脉膏剂的真皮深层以下的组织内可见明显扩张的血管和肥大细胞数量增多。在同体对照或对照组的皮肤组织内，虽也见少量扩张的血管，但明显少于涂药皮肤组织内的血管数量。统计学处理结果显示白脉膏组涂药部位的皮肤组织内血管数量和肥大细胞数量，均明显多于同体未涂药部位和对照组的数量，有非常显著性差异（P<0.01)。结论:白脉膏剂对涂药部位皮肤组织有明显的扩张血管作用和促肥大细胞聚集作用。 |
| English Summary: |
| The effect of Baimai Paste on microcirculation was explored through counts of blood vessels and mastocytes after the Paste was applied to some acupuncture points of nude mice.Methods:15 BALB/C-nu adult nude mice were divided to the treatment group and the no-treatment group， and attended to accordingly. On Day 7， skins of treated areas (around the 4th thoracic vertebra) on the back， of untreated areas of the same subject， and skins of corresponding areas from no-treatment mice were collected， sectioned， stained and observed.Results:an increase of expanding blood vessels and mastocytes were seen in the dermis of the treated areas compared with less increase of those in the no-treatment areas or subjects. Statistics analysis showed very significant differences in increase of blood cells and mastocytes when comparison were made between the treated skin areas and no-treatment areas of the same subject， or the control group (P<0.01).Conclusion:Baimai Paste can significantly expand blood vessels and stimulate aggregation of mastocytes. |
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