To explore the mechanism of immune-mediating of Zhikang Pill in decreasing blood lipid to control the development of atherosclerosis by setting up hyperlipemia models of New Zealand rabbits. Methods:1) Set up hyperlipemia models of New Zealand rabbits; 2) Observe the pathological changes in endarterium;3) Study the effects of Zhi Kang Pill by detecting the levels of C-reactive protein and soluble intercellular adhesion molecule-1 through ELISA. Results:1) Hyperlipidemia models were successfully established by using high-fat diet in New Zealand rabbits; 2) Zhi Kang Pill can effectively reduce blood lipid level and regulate the levels of C-reactive protein and soluble intercellular adhesion molecule-1.Conclusion:Zhi Kang Pill can effectively reduce the level of blood lipid in rabbit and has significant anti-inflammatory effects.