| 引用本文:宋业琳，孙兰军，赵英强，徐强.鹿茸液对慢性心衰大鼠心肌细胞凋亡和Ⅰ、Ⅲ型胶原表达的实验研究[J].世界中医药,2008,3(6):. |
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| 鹿茸液对慢性心衰大鼠心肌细胞凋亡和Ⅰ、Ⅲ型胶原表达的实验研究 |
| Experimental Study on Impact of Hairy Antler Liquid on Apoptosis cadiocyte CHF |
| 投稿时间：2007-11-16 |
| DOI： |
| 中文关键词: 慢性心衰/中医药疗法 @ 鹿茸液 |
| English Keywords:Chronic Heart Failure/ Chinese Medical Therapy @ Hairy Antler Liquid |
| 基金项目: |
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| 中文摘要: |
| 目的：研究鹿茸液对慢性心衰大鼠心肌细胞凋亡和Ⅰ、Ⅲ型胶原表达的影响，讨论鹿茸液治疗心衰的作用和机制。方法：实验采用SD大鼠冠状结扎方法制备心梗后慢性心衰动物模型，随机分为鹿茸液高、中、低剂量组、卡托普利组、模型组和空白组，给予相应的药物干预，4周后观察心肌细胞凋亡，心基质Ⅰ、Ⅲ型胶原的变化情况。结果：鹿茸液各剂量组和卡托普利组CHF大鼠心肌细胞凋亡及Ⅰ、Ⅲ型胶原表达与模型组相比较低，具有统计学差异（P<0.05），鹿茸液中剂量组和卡托普利组之间无统计学差异（P>0.05），均优于鹿茸液高剂量组和低剂量组（P<0.05），鹿茸液高剂量组优于低剂量组（P<0.05）。结论：鹿茸液能够减少CHF大鼠心肌细胞凋亡，减少Ⅰ、Ⅲ型胶原沉淀，从而抑制左室重构，具有良好的临床研究前景。 |
| English Summary: |
| To investigate the treatment effect and its mechanism of Hairy Antler Liquid on CHF by discovering its impact on apoptosis of cadiocyte， expression ofⅠcollagen and Ⅲ collagen.Methods:SD rats with chronic heart failure established by coronary artery ligature were randomly divided to high-dose Hairy Antler Liquid group， middle-dose group， low-dose group， Captopril group， model group and blank group intervened with relevant measures， and observed for apoptosis of cadiocyte， Ⅰcollagen and Ⅲ collagen in cardiac muscles.Results:Compared with those of the model group， all indices of each treatment groups were significantly different (P<0.05). Both being significantly better than other treatment groups in all indices (P<0.05)， middle-dose and Captopril group were not significantly different from each other (P>0.05)， while the high-dose group was better than low-dose group (P<0.05). Conclusion:Inhibiting left ventricular remodeling by reducing apoptosis of cadiocyte， and expression ofⅠcollagen and Ⅲ collagen， Hairy Antler Liquid is of promising clinical application. |
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