To observe the effect of Xiao gu ruan jian Pill on pathological morphous and basic fibroblast growth factor (BFGF) of rats of liver cirrhosis (LC).Methods:The LC rat model was established using multiple inducing factors, the effect of Xiao gu ruan jian Pill on pathological morphous and BFGF were observed with a control group tested with Composite Bie jia ruan gan Tablet.Results:In comparison with normal group, the model group had extensive fibrous tissue hyperplasia with formation of liver pseudolobule and significant increase of BFGF (P<0.01). In comparison with model group, some damage of acini hepatis with small amounts of fibrous tissue hyperplasia and a steady decrease of BFGF (P<0.05 or P<0.01) were found in high-dosage group, low-dosage group of Xiao gu ruan jian, and in the control group, all of which showed no signs of fibrotic septa.Conclusion:We observed Xiao gu ruan jian Pill can lessen the liver damage of rats with LC, and lower BFGF level, so it has remarkable effect of anti-liver fibrosis, blocking LC progress and relieving abdominal dropsy.