With the aim to provide theoretical basis, the study tested the efficacy of catgut embedment in acupoints for treating chronic fatigue syndrome (CFS).Methods:A total of 122 patients were randomly grouped to A (42 cases), B (41 cases), C (39 cases), given respectively symptomatic treatment with western medicines, symptomatic treatment plus embedment, and embedment. Syndrome differentiation was applied to Group B and C.Results:When respectively compared with the total effective rate of 66.67% of Group A, B’s 97.56% and C’s 92.31% were significantly higher.Conclusion:With confirmed curative effect, catgut embedment in acupoints is suitable for widespread clinical application for chronic fatigue syndrome.