To observe the effect of Tongmai Dixian Pills on supersensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) in patients with unstable angina (UA).Methods:Sixty confirmed UA patients were allocated randomly to take orally Tongmai Dixian Pills (12g, 3 times a day), or Shexiang Baoxin Pills (2 pills, 3 times a day) for 30 days. Levels of hs-CRP and Hcy in venous blood from the patients’ empty stomach were determined before and after treatment.Results:When comparing post-treatment vs. prior-treatment, hs-CRP and Hcy levels in both groups were decreased significantly after treatment (P<0.05、P<0.01); and post-treatment hs-CRP level was lower in the treatment group than in the control group (P<0.05). Conclusion:Tongmai Dixian Pills can inhibit inflammatory reaction of coronary artery, prevent thrombosis, which may explain its mechanism to treat unstable angina with the pattern of kidney yang deficiency.