| 引用本文:唐亚平，龚超奇，黄秋粤，李爱媛，戴芳.肝郁脾虚证大鼠TXB2、6-Keto-PGF1α含量的观察研究[J].世界中医药,2009,4(5):. |
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| 肝郁脾虚证大鼠TXB2、6-Keto-PGF1α含量的观察研究 |
| Observation of TXB2、6-Keto-PGF1α on Rats with Liver Depression and Spleen Deficiency |
| 投稿时间：2008-05-19 |
| DOI： |
| 中文关键词: 肝郁脾虚证 TXB2 6-Keto-PGF1α TXB2/6-Keto-PGF1α |
| English Keywords:syndrome of liver depression and spleen deficiency TXB2 6-Keto-PGF1α TXB2/6-Keto-PGF1α |
| 基金项目:广西中医学院高学历人才科研启动基金课题（G 200209） |
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| 中文摘要: |
| 目的：探查肝郁脾虚证大鼠血液运行的状况。方法：采用塑料夹夹尾+隔日禁食+禁食时在鼠笼上方悬挂食物的方法建立肝郁脾虚证大鼠模型，测定其血浆TXB2、6-Keto-PGF1α的含量及TXB2/6-Keto-PGF1α比值。结果：肝郁脾虚证大鼠模型与正常对照组相比，TXB2及TXB2/6-Keto-PGF1α比值明显升高（P<0.01），6-Keto-PGF1α则无明显变化（P>0.05）。结论：肝郁脾虚证大鼠出现了TXA2和PGI2之间平衡的失调，造成血液高黏和易形成血栓，表明肝郁脾虚证大鼠存在着血流不畅或血瘀的状态。 |
| English Summary: |
| To research condition of blood circulation in rats with liver depression and spleen deficiency.Methods:To establish such illness model, we placed plastic clip onto rats’ tails to cause fighting, fed food every other day while keeping food in sight during fasting, measured TXB2、6-Keto-PGF1α、calculated ratio of TXB2/6-Keto- PGF1α. Results:Compared with normal rats, the model group had higher ratio of TXB2/6-Keto-PGF1α along with an increase in TXB2 (P<0.05), 6-Keto-PGF1αdidn’t change significantly (P>0.05).Conclusion:The disproportionate relationship between TXA2 and PGI2 increase risk of thrombus in rats with liver depression and spleen deficiency, suggesting hampered or stagnant blood circulation. |
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