Abstract:To explore clinical efficacy and the mechanism of Yiyi Jiangtang Mixture for type Ⅱ diabetic patients with insulin-resistance.Methods:According to whether there is a complication, eighty patients were stratified and randomized to take Metformin (40 cases), or Yiyi Jiangtang Mixture (40 cases) respectively for 1 month. Clinical efficacy and therapeutic indices of each medication were observed before and after treatment, including FPG, fasting insulin (FIN), postprandial plasma glucose (2h, P2hPG), glycosylated hemoglobin (HbAIc), TC, TG, insulin sensitivity index (ISI), insulin resistance (IR).Results:The trial demonstrated Yiyi Jiangtang Mixture had a significantly higher effective rate of 92.5% than that of Metformin, and few noticeable adverse effects.Conclusion:Yiyi Jiangtang Mixture had significant therapeutic effectiveness for type Ⅱ diabetes and insulin resistance.