To explore clinical efficacy of the compound granules of Jiawei Zhizhu Decoction for constipation.Methods:The positive controlled quantitative and qualitative studies were carried out on two hundred constipation patients, enrolled during the years 2000-2006, who were randomly allocated to receive the granule or the polyethylene glycol laxative.Results:Statistics showed significant differences in the post-treatment effective rate between the two groups (χ2=12.82, P<0.01).Conclusion:Decoction-free compound granules of Jiawei Zhizhu Decoction has confirmed therapeutic effects for constipation, thus is recommend for wide application.