| 引用本文:周义杰，王红，李志英，韦华军，王培力.疏血通对急性脑梗死40例患者血P-、L-选择素表达及炎症的影响[J].世界中医药,2010,5(1):. |
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| 疏血通对急性脑梗死40例患者血P-、L-选择素表达及炎症的影响 |
| Impact of Shuxuetong on P- Selectin and L- Selectin Expression and Inflammation on 40 Patients with Acute Cerebral Infarction |
| 投稿时间：2009-11-09 |
| DOI： |
| 中文关键词: 急性脑梗死/中医药疗法 @ 疏血通注射液 |
| English Keywords:Acute cerebral infarction/ Chinese medical therapy @ Shuxuetong Injection |
| 基金项目:广西卫生厅自筹经费科研课题(E2007189);广西中医学院自然科学研究课题(P2006089) |
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| 中文摘要: |
| 目的：观察疏血通注射液对脑梗死患者P-、L-选择素表达及对炎症反应的影响，研究其干预脑缺血后炎症反应的环节及作用机制。方法：将诊断明确的急性脑梗死住院患者80例随机分为2组，治疗组40例，对照组40例。对照组给予西医常规治疗：抗血小板聚集、控制脑水肿、改善脑血循环、改善脑细胞代谢、防治并发症及支持疗法；治疗组在对照组的基础上加用0.9%生理盐水250mL＋疏血通注射液6mL，每天1次，连续使用14天。对比2组治疗前后临床疗效及P-、L-选择素及炎症指标C反应蛋白（CRP）的变化。结果：治疗组愈显率72.5%,有效率92.5%，高于对照组(50%和75%，P<0.05)。治疗后2组患者临床神经功能缺损评分均有明显改善（P<0.05），治疗组改善更明显（P<0.05）；治疗后2组血P-、L-选择素、CRP均有明显改善（P<0.05），治疗组在血P-、L-选择素、CRP的改善方面优于对照组(P<0.05)。结论：疏血通注射液治疗急性脑梗死患者有较好的疗效，其作用机制与干预急性脑梗死患者P-、L-选择素的表达，调节炎症反应有关。 |
| English Summary: |
| To observe the impact of Shuxuetong on the expression of P- selectin, L- selectin, and C-reactive protein in the condition of acute cerebral infarction, and study the intervention mechanism thereof . Methods:Eighty patients were randomized to receive Shuxuetong (6ml, diluted with 250ml 0.9% Sodium Chloride, once per day) plus routine treatments (anti-platelet aggregation, etc.) for 14 consecutive days, controlled by those receiving the routine treatments only (anti-platelet aggregation, etc.).The clinical effect, P-, L- selectin, and CRP were observed. Results:The significant effective rate (72.5%) and effective rate of (92.5%) of the treatment group were higher than those of the control group (50%, 75%, P<0.05). After treatment, both groups improved in all abovementioned parameters (P<0.05), with the treatment group being significantly better (P<0.05). Conclusion: By intervening the expression of P- selectin, L- selectin, and regulating inflammatory reaction, Shuxuetong Injection has satisfactory therapeutic effect on acute cerebral infarction. |
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