| 引用本文:胡心伟，傅金英，肖新春，张庆文.经轻胶囊对高雌大鼠神经递质影响的实验研究[J].世界中医药,2010,5(1):. |
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| 经轻胶囊对高雌大鼠神经递质影响的实验研究 |
| Impact of Jingqing Capsule on Contents of NT in Rats with high-level Estrogens |
| 投稿时间：2009-11-18 |
| DOI： |
| 中文关键词: @ 经轻胶囊 雌二醇 神经递质 |
| English Keywords:Jingqing Capsule Aquadiol NT |
| 基金项目: |
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| 摘要点击次数: 1477 |
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| 中文摘要: |
| 目的：考察外源性雌激素对大鼠神经递质变化的影响，探讨中药经轻胶囊的干预机制。方法：以皮下注射苯甲酸雌二醇造成大鼠体内高雌激素状态，设立空白对照组、雌激素模型组、雌激素+左洛复组、雌激素+经轻胶囊组，通过对实验大鼠的中枢神经递质5-HT、5-HIAA、NE、DA指标的考察，探讨经轻胶囊对高雌激素诱发的大鼠抑郁状态的可能干预机制。结果：外源性雌激素可造成大鼠中枢神经递质5-HT、5-HIAA、NE、DA的含量显著降低。结论：中药经轻胶囊可升高中枢神经递质的含量，纠正/控制这一状态。 |
| English Summary: |
| To explore the impact of exogenous estrogens on the neurotransmitters (NT) of rats in order to discover the intervention mechanism of Jingqing Capsule. Methods:The rats were injected subcutaneously with benzestrofol to achieve high-level estrogen. The treatment group was given Jiangqiao Capsules decoction and controlled by a normal group, a model group, and a group treated with Zoloft. Through determining the contents of 5-HT、5-HIAA、NE、DA, discussed was a possible intervention mechanism for depression induced by high-level estrogen. Results:Exogenous estrogen can significantly lower the levels of 5-HT、5-HIAA、NE、DA in rats. Conclusion: Jingqing Capsule can treat or control depression induced by high-level estrogen through raising NT contents. |
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