世界中医药

作者	单位
陈耀龙¹，陈淑慧²，指导：陈荣钟³	1 广州中医药大学第一附属医院,广东省广州市机场路14号； 2 广州中医药大学附属广东省中医院； 3 广州中医药大学附属深圳医院针灸科

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中文摘要:

目的：探讨ET、NO在糖尿病胃肠运动功能障碍发病进展过程中的作用和穴位埋线法早期干预的作用机理。方法：采用前瞻性随机对照动物试验，用自制的高脂饲料喂养+链脲佐菌素腹腔注射的方法制作出38只糖尿病模型大鼠，随机分为穴位埋线治疗组和模型空白对照组，每组19只，另外取13只健康大鼠作为正常空白对照组。穴位埋线治疗组大鼠用埋线治疗，7天1次，共埋线12次；模型空白对照组大鼠给予自由饮食，不做任何处理，饲养12周。12周后抽血和取胃窦组织进行血浆内皮素和胃窦一氧化氮（NO)含量的测定。结果：模型空白对照组大鼠血浆内皮素含量明显高于穴位埋线治疗组和正常空白对照组，差异有统计学意义（P<0.05)，穴位埋线治疗组与正常空白对照组血浆内皮素含量比较无统计学意义（P>0.05)；模型空白对照组大鼠胃窦NO含量明显低于穴位埋线治疗组和正常空白对照组，差异有统计学意义（P<0.05)，穴位埋线治疗组与正常空白对照组胃窦NO含量比较无统计学意义（P>0.05)。结论：血浆ET、胃窦NO含量的变化提示糖尿病胃肠局部微循环障碍是糖尿病胃肠并发症的主要病理基础，早期采用穴位埋线法进行干预，能降低ET，升高NO水平。

English Summary:

To discuss the role of endothelin (ET) and nitrogen monoxidum (NO) in gastrointestinal motility dysfunction and the mechanism of catgut embedment at acu-points for early intervention. Methods:In the prospective randomized controlled animal trial, the diabetic model was established on 38 rats by giving lipoproteine rich feeds and intraperitoneal injection of streptozotocin, which were randomized to a positive control group, or be embedded with catgut at acupoints (12 times, once per 7 days). Another 13 healthy rats were taken as normal controls. After 12 week, the contents of ET and NO in sinus ventriculi were determined. Results:The positive control group showed significantly higher ET content, and significantly lower NO content (P<0.05) when compared with the embedment and normal groups, the two of which were not statistically different (P>0.05). Conclusion: The gastrointestinal microcirculation disturbance could be the main pathological basis of the diabetic gastrointestinal compilation, as indicated by the content changes of ET and NO, which can be regulated by acupoint catgut embedment if applied at the early stage.

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