| 引用本文:陈春永，朱迪盈，林少峰.卡培他滨联合草酸铂加健脾散结中药治疗晚期复发食管癌的临床观察[J].世界中医药,2010,5(2):. |
|
| 卡培他滨联合草酸铂加健脾散结中药治疗晚期复发食管癌的临床观察 |
| Effects of Spleen Invigorating and Mass Resolving TCM Medicines on Chemotherapy for Advanced Esophageal Cancer Relapse |
| 投稿时间：2009-12-04 |
| DOI： |
| 中文关键词: 晚期复发食管癌/中医药疗法 健脾理气 卡培他滨 草酸铂 |
| English Keywords:Advanced esophageal cancer relapse/ Chinese medical therapy Spleen invigorating and qi regulating Capecitabine Oxaliplatin |
| 基金项目: |
|
| 摘要点击次数: 1180 |
| 全文下载次数: 1483 |
| 中文摘要: |
| 目的：通过健脾散结中药加上卡培他滨联合草酸铂的方案，比较卡培他滨联合草酸铂的方案治疗晚期复发食管癌的疗效和不良反应。方法：将既往接受过PF方案化疗的复发的晚期食管癌76例，随机分为中药组与对照组各38例。对照组进行化疗同时配合口服大剂量的维生素B6，中药组在化疗同时配合健脾散结中药内服。结果：中药组治疗晚期复发食管癌的有效率（RR）71.1％明显高于对照组44.7％（P<0.05），而在毒副反应方面，譬如恶心呕吐、腹泻、贫血、血小板减少、肝功能损害、白细胞减少、手足综合征、脱发、神经毒性，中药组发生的几率也比对照组明显降低。结论：相对于卡培他滨联合草酸铂的方案，健脾散结中药加上卡培他滨联合草酸铂治疗晚期复发食管癌具有良好的减毒增效的作用，值得进一步的深入研究。 |
| English Summary: |
| To compare efficacy and adverse effect of a chemo therapy (Capecitabine + Oxaliplatin) and the therapy plus spleen invigorating and mass resolving TCM medicines for advanced esophageal cancer relapse.Methods:Seventy six patients with advanced esophageal cancer relapse and past PF chemo treatment, were randomly divided to the TCM group (38 cases) and control group (38 cases) to receive the TCM medicine, or Vitamin B6 respectively in addition to the chemo treatment.Results:The effective rate of the TCM group (71.1%) was significantly higher than that of the control group (44.7%, P<0.05). Such adverse effect as vomiting, diarrhea, anaemia, plate-reduction, liver impairment, aleucocytosis, hand-foot syndrome, alopecie; neurotoxicity were also significantly reduced in the TCM group compared to the control group.Conclusion:Spleen invigorating and mass resolving TCM medicine can enhance efficacy and reduce adverse effect of the chemo treatment for advanced esophageal cancer relapse. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
