Although sub-health has a variety of causes, it is closely related to individual constitution and temperament. Constitution and temperament, a high generalization of the form and spirit theories concerning body and mind, unmistakably demonstrate the individualization that is characterized of Chinese medicine. As a result, the prevention, treatment and intervention of sub- health should be carried out through individualized plans and strategies. Sub- health treatments according to differentiated individual-based mental and physical "quality" will have much significance in the 21 century.