To study effect of Sanqi sodium hyaluronate gel (the gel) on apoptosis of fibroblast in rabbits' epidural scar.Methods:After laminectomy, the rabbits were treated with Sanqi gel, Sanqi concentration, Sanqi sodium hyaluronate and saline respectively. At 2nd, 4th and 8th week after operation, apoptosis was observed by the Tunel and expression of Caspase-3 was detected by hybridization in situ.Results:At all time points apoptosis of gel group were greater than of sodium hyaluronate and saline（P<0.01）, and statistically same with concentration at 2nd week. Hyaluronate treated group is statistically the same with saline group. The expression of Caspase-3 in gel group was higher than other groups at 2nd week（P<0.05）, of which concentration group was significantly higher than saline group; There was no difference at 4th week; at 8th week, the gel group is remarkably higher than saline group（P<0.01）, concentration group （P<0.01）and hyaluronate group (P<0.05) .Conclusion:Sanqi gel could induce fibroblast apoptosis throup up-regulating of Caspase-3expression, while sodium hyaluronate showed little impact on thereof.