| 引用本文:白雪松，蔡光先，尹天雷.经方补阳还五汤对神经功能缺失影响的一种药理学评价方法[J].世界中医药,2011,6(3):. |
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| 经方补阳还五汤对神经功能缺失影响的一种药理学评价方法 |
| A pharmacology method to estimate effect of Buyang Huanwu Decoction on neurologic deficits of MCAo Model Rat |
| 投稿时间：2011-03-17 |
| DOI： |
| 中文关键词: 补阳还五汤 神经损伤严重度评分 中药药理学 |
| English Keywords:Buyang Huanwu Decoction Neurological Severity Score(NSS) Pharmacology of Traditional Chinese Medicine |
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| 中文摘要: |
| 目的：观察补阳还五汤对脑梗死动物模型大鼠神经损伤严重度评分（NSS）的影响。方法：采用线栓法复制大脑中动脉梗死动物模型，实验动物随机分为模型组、补阳还五汤组，每组10只，另取10只同批次的动物作为空白对照组。在造模2周后开始给药，共给药6周。并在给药前，给药后2、4、6周进行神经损伤严重度评分。结果：动物造模后出现一侧的感觉、运动、反射等神经功能障碍，造模动物（模型组、补阳还五汤组）NSS评分下降（与空白组比较P<0.01），并随时间发展，有一定的恢复（模型组各时点比较P<0.01）。补阳还五汤能促进神经缺失的康复（与模型组各时点比较，P<0.01或<0.05）。结论：补阳还五汤具有改善脑梗死模型大鼠神经损伤严重度评分的作用。 |
| English Summary: |
| To observe effect of Buyang huanwu Decoction on Neurological Severity Score(NSS) of MCAo model rat. Methods:MCAo rat models were reproduced by Intraluminal Suture. Twenty survivals were classified into two groups after 2 weeks: model group (n=10) and Buyang Huanwu Decoction group (n=10), in comparison with other ten normal rats. Each rat was scored by NSS at baseline, week2, week4, and week6. Results:Model rats showed neurologic deficits and decreased NSS scores compared with normal rats (P<0.01). The neurologic deficits showed certain degree of spontaneous recovery. The score of Buyang Huanwu Decoction group were significantly higher than those of model group at different time points (P<0.01 or P<0.05). Conclusion: Buyang Huanwu Decoction can improve Neurological Severity Score in MCAo model rats. |
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