世界中医药

作者	单位
李天朗¹，唐志宇²，王祖祥¹，付勇¹，温月¹	1 四川省德昌县人民医院，四川省凉山彝族自治洲德昌县德州镇东风路20号,615500； 2 广州中医药大学

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中文摘要:

目的：观察中药分期治疗对兔骨折延迟愈合X线及血清碱性磷酸酶（ALP）的影响。方法：新西兰兔75只，无菌术下左侧桡骨中下1/3切除10mm后，除模型组外其余4组髓腔用骨腊封闭，分为治疗1组、治疗2组、治疗3组、模型组、延迟愈合模型组，每组15只。其中治疗2组术后按骨折分期第2天开始给药，治疗3组和治疗1组4周成模后给药，延迟愈合模型组和模型组术后第2天灌等容量的生理盐水，延迟愈合模型组成模后骨延迟愈合区注入自体红骨髓。术后第4周和8周检测血清ALP和拍摄线片。结果：第4周治疗2组血清ALP明显高于其他4组，差异极显著（P<0.01），第8周与延迟愈合模型组比较差异极显著（P<0.01），与模型组比较差异显著（P<0.05），治疗1组和治疗3组血清ALP与模型组比较显著下降（P<0.05），与治疗2组比较无显著性差异（P>0.05）。第4周末X线肉眼评分模型组极显著高于其他各组，第8周末治疗2组肉眼评分显著高于治疗1组和治疗3组及延迟愈合模型组（P<0.01），与模型组无明显差异（P>0.05）。结论：中药分期治疗明显提高了骨折X线肉眼评分，治疗2组血清ALP明显提高，中药组均有促进骨折愈合的作用。

English Summary:

To investigate impact of Chinese medicine treatment per phase on X ray film and serum ALP level in fractured rabbits. Methods:75 New zealand rabbits with fracture were equally divided to treatment group 1 to 3, model group (group 4) and delay union group(group 5). From Day2, group 2 was administered with Chinese medicine per fracture phase, group 4 and group 5 received same volume physiological saline, from Week4 group 1 and group 3 began treatment. Delay union group was injected with red marrow after establishment of modeling. At Week4 and Week8 following operation, serum ALP and X ray film were taken. Results:At Week4 ALP level of group2 was significantly higher than that of the rest groups (P<0.01), and kept at significant higher level in comparison with the model group and delay union group at Week 8. There wasn’t significant ALT difference between group 1 and group 2. At Week4 the model group had the highest score per X ray film, at Week8 the score of group2, higher than other groups, was not significantly different with the score of model group. Conclusion: Chinese medicine treatment per fracture phase can significant increase X-ray score and serum ALP level. The groups given Chinese medicine treatment can improve union of fracture.

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