To investigate the application value of Iris diagnosis in stage classification and syndrome differentiation of chronic kidney disease (CKD). Methods:A total of 150 CKD patients and 30 healthy subjects were observed in terms of occurrence of Iris disease sites, intensity, color using Iris scope DC-106 manufactured by Mikky Corp. Results:Compared with the occurrence of Iris disease sites, intensity, color of the control group, the CKD group had significant difference (P<0.01). The change of iris is positively related to phase categorization and syndrome change of CKD. Conclusion:Iris diagnosis by iris scope is very helpful to diagnose chronic kidney disease at early stage.