| 引用本文:王丹丹1，皇甫辉2.鼻炎宁颗粒辅助治疗变应性鼻炎的临床观察[J].世界中医药,2012,7(3):. |
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| 鼻炎宁颗粒辅助治疗变应性鼻炎的临床观察 |
| Clinical trial of Biyanning Granule as Complementary Treatment of Allergic Rhinitis |
| 投稿时间：2012-02-09 |
| DOI： |
| 中文关键词: 鼻炎宁颗粒 布地奈德鼻喷剂 盐酸西替利嗪片 变应性鼻炎 |
| English Keywords:Biyanning Granule Budesonide Nasal Spray Cetirizine Hydrochloride Tablets Allergic rhinitis |
| 基金项目: |
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| 摘要点击次数: 1268 |
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| 中文摘要: |
| 目的：观察鼻炎宁颗粒用于治疗中重度持续性变应性鼻炎的疗效、对生活质量影响及其安全性。方法：入选的中重度持续性变应性鼻炎患者177例，按就诊的先后次序随机分为A组、B组和C组。A组治疗采用布地奈德鼻喷雾剂喷鼻。B组为布地奈德鼻喷雾剂喷鼻，同时冲服鼻炎宁颗粒。C组为布地奈德鼻喷雾剂喷鼻，同时口服盐酸西替利嗪片。治疗结束后对3组疗效、治疗前后生活质量改善情况及不良反应进行分析比较。结果：治疗1周后A、B、C组有效率分别为47％、67％、74％，A组有效率分别与B、C组比较，差异有统计学意义(P<0.05)，B组有效率与C组比较差异无统计学意义(P>0.05)。治疗2周后A组、B组、C组有效率分别为60％、79％、82％，A组有效率分别与B、C组比较，差异有统计学意义(P<0.05)，B组有效率与C组比较差异无统计学意义(P>0.05)。3组患者治疗前后总体生活质量评分差异均有统计学意义（P<0.05）；治疗后总体生活质量评分比较，A组与B、C组差异有统计学意义(P<0.05)，B组与C组差异无统计学意义(P>0.05)。所有患者治疗过程中均未出现严重不良事件。A、B、C组不良反应发生率分别为13.3%、15.3%、22.4%，未见鼻炎宁颗粒相关不良反应发生。结论：鼻炎宁颗粒治疗中重度持续性变应性鼻炎有一定的疗效，与布地奈德鼻喷剂联合应用时其作用与盐酸西替利嗪片相当，且不良反应少。 |
| English Summary: |
| To evaluate the efficacy and safety of Biyanning Granule on moderate to severe persistent allergic rhinitis.Methods:To compare efficacy, quality of life, safety of Biyanning and Cetirizine hydrochloride tablet on top of Budesonide nasal spray in 177 patients.Group A was treated with Budesonide nasal spray, group B with Budesonide plus Biyanning Granule, group C with Budesonide plus Cetirizine hydrochloride tablet.Results:After one week,the effective rates of group A, B and C was 47％,67％ and 74％,and there was significant difference between group A and B or A and C(P<0.05), but not significant between group B and C(P>0.05).After two weeks, the effective rates of group A, B and C was 60％, 79％ and 82％,there was significant difference between group A and B or A and C(P<0.05),but not significant between group B and C(P>0.05).There was significant improvement of quality of life after treatment for all groups (P<0.05).Quality of life of Group A was significantly better than that of group B or C, but not significant between group B and C.Without severe adverse reaction, the AE occurence rates were 13.3 %,15.3 % and 22.4 %.Conclusion:Biyanning Granule has corrective efficacy for moderate to severe persistent allergic rhinitis.The combined effect with Budesonide nasal spray is as good as Cetirizine Hydrochloride with less adverse drug reactions. |
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