To discuss the relationship between various endocrine or immunological factors and TCM syndromes of chronic aplastic anemia(CAA), and to establish an equation to determine TCM syndromes.Methods:77 CAA patients were divided to kidney-yang deficiency group, kidney-yin deficiency group and kidney-yin-yang-deficiency group.Endocrine or immunological parameters of the patients were assessed and compared with 20 healthy volunteers, in order to establish an equation to identify their TCM syndromes, and to analyze the correlations.Results: 1) CD3, CD4, CD8, CD3+28+, C3, C4, IgA, FT4 have different levels in three CAA groups. 2) Absolute value of Hb(g/L), PLT(×109/L), CD55(%), CD8(%), CD+3CD+95(%), IgA(g/l), C3(g/l), C4(g/l), FT4(ng/dl) were selected to form a discriminatory formulas.Conclusion:CD3, CD4, CD8, CD3+28+, C3, C4, IgG, FT4 can be the indicators suggestive of TCM syndromes of CAA in clinical practice.The establishment of the equation for syndrome differentiation is objective, quantitative and clinically meaningful.