| 引用本文:范新六1，3，李峰2，宋月晗2，洪志强3，马佳美2，刘燕2.加味四逆散对睡眠剥夺大鼠PFC和海马CA3区NMDA受体表达的调节作用[J].世界中医药,2012,7(3):. |
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| 加味四逆散对睡眠剥夺大鼠PFC和海马CA3区NMDA受体表达的调节作用 |
| Regulation of Jiawei Sini Powder on Expression of PFC and CA3 NMDA Recepters |
| 投稿时间：2012-02-28 |
| DOI： |
| 中文关键词: 睡眠剥夺 加味四逆散 NMDA受体 |
| English Keywords:Sleep deprivation Jiawei Sini Powder NMDA recepter |
| 基金项目:国家自然科学基金（NO.30873217） |
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| 中文摘要: |
| 目的：研究睡眠剥夺大鼠PFC和海马CA3区NMDAR 2B和NMDAR 2B（Tyr1472）表达的变化，并观察加味四逆散对其影响。方法：采用多平台法，进行连续睡眠剥夺168h，使用Western blot技术分析大鼠PFC和海马CA3区NMDAR 2B和NMDAR 2B（Tyr1472）表达的变化。结果：与对照组比较，模型组大鼠PFC和海马CA3区NMDA受体NMDAR 2B和NMDAR 2B（Tyr1472）蛋白质的表达明显减少（P<0.05）。与模型组比较，加味四逆散组大鼠PFC和海马CA3区NMDAR 2B和NMDAR 2B（Tyr1472）蛋白质的表达均明显增加（P<0.05）。结论：加味四逆散能上调睡眠剥夺导致PFC区NMDAR2B、NMDAR2B（Tyr1472）表达的降低；也能上调睡眠剥夺导致海马CA3区NMDAR2B表达的降低。 |
| English Summary: |
| To investigate expression of PFC, NMDAR 2B and NMDAR 2B(Tyr1472) in rats deprived of sleep, and the impact of Jiawei Sini Powder.Methods:Using multi-platform to deprive rats of sleep for consecutively 168h, and using Western blot to analyze changes of expression of PFC, NMDAR 2B and NMDAR 2B(Tyr1472).Results:Compared with control group, the model group decreased significantly in above mentioned expressions (P<0.05).Compared with the model group, the rats taken Jiawei Sini Powder had the expressions increased significantly (P<0.05).Conclusion:Jiawei Sini Powder can raise the decreased expressions of PFC, NMDAR 2B and NMDAR 2B(Tyr1472) in rats caused by sleep deprivation. |
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