| 引用本文:邓丽丽，宋殿荣，胡丽萍，王跃飞.寿胎丸提取液透过妊娠大鼠胎盘屏障的药物成分研究[J].世界中医药,2012,7(4):. |
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| 寿胎丸提取液透过妊娠大鼠胎盘屏障的药物成分研究 |
| Study on ingredients of Shou Tai Wan extract through placental barrier of rat in pregnancy |
| 投稿时间：2012-05-21 |
| DOI： |
| 中文关键词: 寿胎丸 马钱子苷 槲皮苷 胎盘屏障 HPLC |
| English Keywords:Shou Tai Wan Loganin Quercitrin Placental barrier HPLC |
| 基金项目:国家科技部中医药行业专项（编号：200707011） |
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| 中文摘要: |
| 目的：对不同孕期妊娠大鼠给予寿胎丸提取液（STW），采用HPLC研究STW透过胎盘屏障的药物成分。方法：早、中、晚孕期Wistar大鼠灌胃STW，连续给药5天后，取母体血浆（母血）、脐静脉血及胚胎组织，用HPLC法检测其中所含药物成分。结果：在实验剂量下，各孕期1h母血中均检测到马钱子苷和槲皮苷，12h母血、脐静脉血及胚胎组织中均未检测到待测成分。结论：实验剂量下，STW的药物成分未透过胎盘屏障，提示妊娠期应用寿胎丸不会造成胎儿的宫内暴露。 |
| English Summary: |
| Use HPLC to study the permeation of ingredients of Shou Tai Wan extract(STW) through placental barriers of Wistar rats at different stages of pregnancy.Methods:The pregnant rats were administered by gavage STW for 5 days at early，middle and late stages of pregnancy. Hepatic portal vein plasma，umbilical veins plasma (at late stage of pregnancy) and embryonic tissues were obtained 1 h，12 h after the final administration of STW. The compounds in biological specimens were identified by HPLC.Results:Among the range of experimental doses，loganin and quercitrin were main compounds in 1 h maternal blood but nothing could examined in 12 h maternal blood，umbilical veins plasma and embryonic tissues at different stages of pregnancy.Conclusion:Under the range of experimental doses，the compounds of STW didn’t permeate through placental barriers of rats. This result showed that the application of STW is safe to embryo in pregnancy. |
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