| 引用本文:阎 峻 杨 敏.中西医结合疗法在急性冠状动脉综合征急诊介入治疗中的应用[J].世界中医药,2012,7(6):. |
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| 中西医结合疗法在急性冠状动脉综合征急诊介入治疗中的应用 |
| Emergency Interventional Therapy in Patients with Acute Coronary Syndrome with Combination of Traditional Chinese and Western Medicine |
| 投稿时间：2012-09-27 |
| DOI： |
| 中文关键词: ST段抬高急性冠状动脉综合征/中西医结合疗法 替罗非班 四妙勇安汤 |
| English Keywords:ST elevation acutecoronary syndrome/Integrated Chinese and Western medicine Tirofiban Simiaoyongan decoction |
| 基金项目: |
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| 中文摘要: |
| 目的：观察中西医结合疗法在急性冠状动脉综合征(ACS)经皮行冠状动脉介入治疗(PCI)中的安全性和近期疗效。方法：277例行PCI的ST段抬高ACS患者随机分成2组，治疗组(n=140)运用替罗非班和四妙勇安汤，对照组(n=137)未使用替罗非班组和四妙勇安汤。观察2组患者用药后TIMI血流分级、出血情况、记录住院期间及随访3个月时的主要心血管事件(心源性死亡、非致死性心肌梗死及再发心绞痛)的发生率。结果：用替罗非班组达到TIMI3级血流的患者为91.43%；对照组达到3级血流的患者为81.029%，2组差异有统计学意义(P<0.05)。2组出血发生率比较无统计学意义(P>0.05)。住院期间和随访3个月均无主要心血管事件发生。结论：在常规药物基础上加用替罗非班和四妙勇安汤治疗高危ST段抬高ACS是安全且有效的。 |
| English Summary: |
| To observe the safety and short-term outcomes of domestic tirofiban in patients with ST elevation acutecoronary syndrome(STEACS) undergoing percutaneous coronary intervention (PCI).Methods:Two hundred and seventy-seven patients with STEACS were enrolled in the study and divided into two groups:the tirofiban group (n=140) and the control group(n=137).TIMI grade,bleeding rate in both groups were investigated and compared before and after PCI. Major adverse cardiac events were also recorded in hospital and during 3 months’ follow-up.Results:Ninty-one percent of patients in the tirofiban group compared with 81% in the control group obtained TIMI grade 3 flow (P<0.05).There was no significant difference in the incidence of bleeding between two groups(P>0.05).There were no serious bleeding complications and MACE in-hospital and follow-up period.Conclusion:Additional use of tirofiban on the basis of conventional drug is safe and effective in thetreatment of high-risk ST elevation acutecoronary syndrome. |
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