| 引用本文:欧凌君 陈文鑫 刘德桓 叶 靖 苏 齐 庄清芬 吴志阳.血脂清对高血压病合并代谢综合征患者载脂蛋白B/载脂蛋白A1的影响[J].世界中医药,2012,7(6):. |
|
| 血脂清对高血压病合并代谢综合征患者载脂蛋白B/载脂蛋白A1的影响 |
| Influence of Xuezhiqing Granule on Apolipoprotein B/Apolipoprotein A1 of Hypertension Patients Complicated with Metabolic Syndrome |
| 投稿时间：2012-07-21 |
| DOI： |
| 中文关键词: 高血压病 代谢综合征/中医药疗法 ApoB/ApoA1比值 血脂清颗粒 阿托伐他汀 |
| English Keywords:Hypertension Metabolic syndrome/Chinese medical therapy ApoB/ApoA1 ratio @Xuezhiqing granule Atorvastatin |
| 基金项目:泉州市科技局重点项目（编号：2009Z40） |
|
| 摘要点击次数: 1200 |
| 全文下载次数: 991 |
| 中文摘要: |
| 目的：观察中药血脂清颗粒对高血压病合并代谢综合征患者ApoB、ApoA1和ApoB/ApoA1的影响。方法：将90例患者按随机数字表法分为3组，每组各30例，阿托伐他汀组给予立普妥10mg，qd，血脂清组给予血脂清颗粒1包，tid，联合治疗组给予立普妥10mg，qd，加血脂清颗粒1包，tid治疗。疗程8周，观察治疗前后ApoB/ApoA1比值及其他血脂参数的变化。结果：治疗8周后，3组ApoB/ApoA1、ApoB均较治疗前显著下降(P<0.01)；阿托伐他汀组和血脂清颗粒的ApoA1均有逐渐增高趋势，但差异无统计学意义(P>0.05)，组间比较差异亦无统计学意义(P>0.05)；而联合治疗组ApoA1、HDL-C均增高，治疗前后自身比较差异有统计学意义(P<0.01)，与其他2组组间比较差异有统计学意义(P<0.05)。结论：血脂清颗粒能改善高血压病合并代谢综合征患者的血脂紊乱，降低ApoB/ApoA1比值，与阿托伐他汀联合使用疗效更显著。 |
| English Summary: |
| To observe the influence of Xuezhiqing granule on ApoB，ApoA1 and ApoB/ApoA1 of hypertension patients complicated with metabolic syndrome. Methods:According to the table of random number method，90 patients were divided into three groups，Atorvastatin Group，Blood fat clear Group and Combined treatment Group，with 30 cases in each group. Atorvastatin Group and Blood fat clear Group were given lipitor 10 mg/qd，blood fat clear grain 1 bag/tid respectively. Combined treatment group was given lipitor 10 mg/qd and blood fat clear grain 1 bag/tid. After a treatment for 8 weeks，the change of ApoB/ApoA1 ratio and other blood lipid parameters were observed before and after treatment. Results:After 8 weeks，the ratio of ApoB/ApoA1 and ApoB had declined significantly than before in 3 groups（P<0.01）. The ratio of ApoA1 had the trend of gradual growth both in Atorvastatin Group and Blood fat clear Group，but the difference was not statistically significant（P>0.05）. Among groups comparative differences also had no statistical significance （P>0.05）.But the ratio of ApoA1 and HDL-C had increased t in Combined Treatment Group，which had statistical significance for itself before and after treatment (P< 0.01)，it also had significant differences compared with other groups. Conclusion: Xuezhiqing granule can improve the symptoms of hypertension patients complicated with metabolic syndrome，reduce the ratio of ApoB/ApoA1，and will have more remarkable curative effect when combined with atorvastatin. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
