To study the regulation effects of Huoxue Shutong Mixture on blood lipid. Methods:The hyperlipidemia model of mouse established by ig high fat emulsion had the serum content of TC, TG, LDL-C, HDL-C detected. We used subcutaneous injection of adrenaline and ice bath to establish the rat model of acute blood stasis, and determined whole blood high cutting, middle and low shear viscosity, plasma viscosity, whole blood reduction viscosity and hematocrit. Rats with ig 12 days had the platelet aggregation rate of 1. 5 min and the maximal aggregation rate determined. Results:The high dose group of Huoxue Shutong Mixture can decrease the serum content of TC, TG, LDL-C, increase the content of HDL-C, reduce whole blood high, medium, low viscosity, plasma viscosity, blood hematocrit viscosity and the platelet aggregation rate of 1.5 min, and the maximal aggregation rate. Conclusion:Huoxue Shutong Mixture can regulate blood lipid.