To investigate prescription, preparation process and in vitro release of Liangfu stomach floating tablets. Methods: The orthogonal design was used to determine the formulation containing the fiber （HPMC） and sixteenth alcohol, sodium carbonate hydrogen, the sodium starch sodium （CMC-Na） as adjuvant material, and in vitro release of and floating was tested. Results: The delay time was less than 5min, floating time was more than 12h, 12h of dose release reached more than 90 %. Conclusion: The Liangfu stomach floating tablets have good floating and release characteristics.