| 引用本文:沈洪丽 韩 玉 苗晓云 回 志 代庆春 张晓卫.血必净治疗脓毒症患者临床疗效观察[J].世界中医药,2013,8(1):. |
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| 血必净治疗脓毒症患者临床疗效观察 |
| Clinical Effectiveness and Impact of Xuebijing Injection on Inflammatory Cytokines of Septic Patients |
| 投稿时间：2012-09-14 |
| DOI：10.3969/j.issn.1673-7202.2013.01.017 |
| 中文关键词: 脓毒症 TNF-α IL-8 CRP 血必净注射液 |
| English Keywords:Sepsis Xuebijing Injection TNF-α IL-8 CRP |
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| 中文摘要: |
| 目的：观察中药血必净注射液对脓毒症治疗效果。方法：选脓毒症患者40例随机，分为2组。对照组和血必净组，每组20例。治疗组和对照组分别如何治疗，监测患者体温并分别于治疗前、治疗3d、治疗7d采静脉血检测血常规、C-反应蛋白（CRP）、TNF-α，IL-8。结果：2组患者治疗均有效，血必净组体温、白细胞计数较对照组水平下降，血TNF-α、IL-8及CRP浓度随病情好转，浓度随之下降，血必净组下降明显，28d病死率及住ICU时间较对照组下降。结论：中药血必净能够降低炎症介质水平，改善脓毒症预后，缩短住ICU时间，从而降低总住院费用。 |
| English Summary: |
| To investigate the clinical effectiveness of Xuebijing injection on septic patients. Methods:Forty patients were randomized to control group (n=20) and xuebijing group (n=20). Both groups were treated according to 2008 sepsis guideline. Xuebijing group added xuebijing 100mL + 0.9% NS 100mL， bid， 7days for one period. Body temperature was monitored and 3ml blood was collected before treatment， 3days and 7days after treatment and stored in -80℃. TNF-α， IL-8 and CRP were determined by the method of ELISA and immunoturbidimetry.Conclusion:Xuebijing injection can degrade inflammatory cytokines， improve sepsis prognosis， and reduce the length of ICU stay， so the expense of hospitalization can be decreased. |
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