世界中医药

目的:观察银杏叶片对具有高尿酸血症的轻度认知障碍(mild congnitive impairment，MCI)患者认知功能的影响。方法:选取69例高尿酸血症合并MCI患者，随机分为治疗组(35例)和对照组(34例)，2组均给予基础治疗，为口服别嘌呤醇0.1g/次，3次/d，治疗组加服银杏叶片，每次1片，每天3次，连续服用3个月。检测2组治疗前、治疗后的简易精神状态检查(mini-mental state examination，MMSE)积分、画钟试验(clock drawing task，CDT)积分、MMSE疗效、CDT疗效及痴呆转化率。结果:2组治疗前MMSE、CDT积分比较，差异无统计学意义(P>0.05)。与本组治疗前比较，治疗组治疗后各指标均升高，且高于对照组，差异均有统计学意义(P<0.05)。治疗组MMSE、CDT总有效率(MMSE为74.3%，CDT为68.6%)均高于对照组(MMSE为41.2%，CDT为38.2%)，差异均有统计学意义(P<0.01)。治疗组痴呆转化率(5.71%)低于对照组(17.6%)，差异有统计学意义(P<0.05)。结论:银杏叶片3个月干预MCI患者，能够较好地改善认知功能，并初步观察到能降低痴呆的转化率。

English Summary:

To observe the effect of Ginkgo Biloba Tablet (GBT) for mild cognitive impairment (MCI) in hyperuricemia patients. Methods:A total of 69 MCI and hyperuricemia patients from our medicine clinic were randomly divided into the control group (34 cases) and the treatment group(35 cases). Basic treatment of Zyloric， 0.1， 3 times a day was given to both groups. Besides， the treatment group was also given GBT 1 tablet each time， 3 times a day， and 3 months in all. The mini-mental state examination (MMSE) scores， clock drawing task (CDT) scores， MMSE efficacy， CDT efficacy， and dementia conversion rate were detected before and after treatment. Results:There was no significant difference in scores of MMSE and CDT between the two groups before treatment (P>0.05). Compared with before treatment， scores in the treatment group remarkably increased after treatment (P<0.01)， and the increases were higher than those of the control group (P<0.05). The total effective rate of MMSE and CDT of the treatment group (MMSE 74.3%;CDT 68.6%) all exceeded those of the control group (MMSE41.2%;CDT38.2%) (P<0.01). The dementia conversion rates after treatment (5.71%) were lower in the treatment group than in the control group(17.6%) (P<0.05). Conclusion:GBT used for 3 months can significantly improve the cognitive function of MCI patients， and also can lower the dementia conversion rate.

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