To observe the therapeutic effect of Banxia Xiexin Decoction HP infected patients failed in triple eradication therapy.Methods:A total of 100 patients failed in thriple eradication therapy were selected and randomly divided into two groups in our hospital.Control group（n=50）were treated with Domperidone and Compound Bismuth Aluminate Granules，meanwhile observation group (n=50)were treated with Banxia Xiexin Decoction.The patients of the two groups were treated for four weeks，after it，followed up for four weeks.At last，HP radical rate，efficacy and safety of Banxia Xiexin Decoction HP were evaluated in the end of the observation. Results:HP radical rate of the two groups respectively was 84.0% and 54.0%，the rate of treatment group was higher than control group with Statistical analysis (P<0.05)，the cure rate of the two groups respectively was 80.0% and 48.0%，while the effective rate respectively was 96.0% and 74.0%，then we can see obviously，both of the cure rate and the effective rate of treatment group were predominantly higher than that of the control group (P<0.05).The security of two groups had significant difference (P<0.05)，the observation group was better than the control group in safety.Conclusion:Banxia Xiexin Decoction applied to triple radical gastric HP failure patient was better than Domperidone and Compound Bismuth Aluminate Granules in HP radical rate，cure rate and the effective rate，and which was more safety.