| 引用本文:卢雯平 徐兵和 姜翠红 高雅静 马 飞 车焕丽 郑洪刚 李道睿 石闻光 张培彤 林洪生.中药对中晚期三阴乳腺癌的生存影响及中医治疗策略探讨[J].世界中医药,2013,8(1):. |
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| 中药对中晚期三阴乳腺癌的生存影响及中医治疗策略探讨 |
| Effect of Herbs on Progress-free Survival in Clinical Stage II～IV Triple Negative Breast Cancer and Strategy of Traditional Chinese Medicine |
| 投稿时间：2012-08-07 |
| DOI：10.3969/j.issn.1673-7202.2013.01.020 |
| 中文关键词: 辨证中药 三阴乳腺癌 无进展生存 生存质量 |
| English Keywords:Chinese medicine according to syndrome differentiation Triple negative breast cancer Progression-free survival Quality of life |
| 基金项目:中国中医科学院乳腺癌优势病种课题资助(编号：CACMSO7Y0015) |
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| 中文摘要: |
| 目的:观察辨证服用中药对三阴乳腺癌的生存影响并探讨中医治疗策略。方法：采用队列研究的方法依据治疗方法的不同将101例三阴乳腺癌分为2个队列，辨证服用中药联合西医治疗队列及单纯西医治疗队列。中药1剂/d，服药至少半年或至肿瘤进展;西医按照美国综合癌症治疗网指南给予相应的治疗。随访3年观察患者3年疾病无进展生存(PFS)及患者生存质量。结果：Kaplan–Meier生存曲线显示，中西医结合组的3年PFS较单纯西药治疗组显示一定优势，有统计学意义(P<0.05)。COX回归分析2组未见统计学意义(P>0.05)。化疗脑及肢体麻木症状在服药1个月后统计显示有明显改善(P<0.05)。结论：辨证服用中药可能对患者的生存有益，需要扩大病例数进一步研究证实。中药可改善因化疗引起的麻木及化疗脑，从而提高生活质量。 |
| English Summary: |
| We observed the effect of Chinese medicine， given as a result of syndrome differentiation， on the progress-free survival and life quality of patients with triple negative breast cancer (TNBC) as well as the strategy of traditional Chinese Medicine. Method: 101 patients at stage II/IIII/IV were divided into two cohorts， of which 65 cases were treated with combination of herbs and standard western medicine and 36 cases by the western medicine alone. Progress-free survival and symptoms like numbness and chemo-brain were evaluated. Results:During 36-month follow-up， there was a statistically significance in DFS by Kaplan-meier although no significance in DFS by COX， and there were significances in improvement of numbness and chemo-brain in combination. Conclusion:Chinese medicine treatment according to syndrome differentiation， may be beneficial to patients with TNBC， the efficacy needs to be further proved on a larger number of patients. Chinese medicine can improve quality of life by relieving the symptoms such as numbness and chemo brain caused by chemotherapy. |
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