| 引用本文:宋明福 刘 敏.化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF－α的影响[J].世界中医药,2013,8(1):. |
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| 化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF－α的影响 |
| Effect of Stasis Removing Herbs plus RNA-based Drugs on TNF- alpha in Mice with Ulcerative Colitis |
| 投稿时间：2012-06-25 |
| DOI：10.3969/j.issn.1673-7202.2013.01.030 |
| 中文关键词: 溃疡性结肠炎 肿瘤坏死因子 化瘀药 核糖核酸 |
| English Keywords:UC TNF-α Stasis removing herbs RNA |
| 基金项目:湖北省重点科技发展项目立项课题（编号：2001AA309B04） |
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| 中文摘要: |
| 目的：观察化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF-α的影响。方法：选择小鼠42只，雌雄兼用，如何分组分为对照组、RNA、氟哌酸治疗组。治疗8 d后测TNF-α的量的变化。结果：经RNA治疗后，查TNF-α水平降至正常（P<0.01）。对照组及氟哌酸组如何。结论：化瘀中药加RNA治疗溃疡性结肠炎疗效明显，能使这一内科顽症在短时间内恢复，其作用机制之一是降低血清TNF-α水平。 |
| English Summary: |
| To observe the effect of stasis removing herbs plus RNA-based drugs on TNF- alpha in mice with ulcerative colitis (UC). Methods:A total of 42 mice with UC， female or masculinity were chosen and divided into three groups， control group， stasis removing herbs plus RNA-based drugs group and norfloxacin group. After eight-day observation and treatment， we measured the changes of TNF-α. Results:The stasis removing herbs plus RNA-based drugs group presented obvious therapeutic effect. The level of TNF-α reduces to the normal level (P<0.01). Conclusion:Stasis removing herbs plus RNA-based drugs have obvious therapeutic effect on UC， and one of its mechanisms is to reduce the level of TNF-α. |
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