ED occurrence is closely related to the incidence of collateral diseases, and the stasis and blockage of collaterals is the key pathogenesis of ED, while not enough attention has been given to it.This paper discussed the pathogenesis of ED, the relevance between ED and collateral disease, the connection between blood stasis and collaterals, and also introduced the modern medicine studies on treating ED from the respective of stasis. Meanwhile, different therapies for different syndrome differentiations were introduced in accordance with ED-collateral disease theories. It provided new treating thoughts for clinical treatment of ED.