To observe the curative effect of Astragalus Injection combined with Ligustrazine in treating type 2 diabetic nephropathy. Methods:A randomized, controlled method was adopted. A total of 64 cases of diabetes nephrosis patients were recruited and divided randomly into control group and treatment group. The control group (32 cases) was only given regular treatment to control blood sugar and blood pressure. Based on this, 32 cases in treatment group were treated with Astragalus injection combined with ligustrazine by intravenous drip. 24-hour urine protein, serum creatinine, blood urea nitrogen, and fibrinogen change were observed. Results: After treatment, indicators of control group such as part of the serum creatinine, blood urea nitrogen, 24-hour urine protein improved; while the index of serum creatinine, blood urea nitrogen, 24 h urine eggs, fibrinogen, cholesterol and triglyceride in treatment group improved after treatment; and the treatment group was significantly improved than control group. Conclusion: On the basis of well controled blood sugar and blood pressure, Astragalus injection combined with ligustrazine can decrease blood fat, blood fibrinogen level, and blood viscosity, relieve the statement of renal high infusion, improve the renal hemodynamics, so as to protect the renal function.